发明名称 |
Transgenic mouse whose genome comprises a homozygous disruption of its alpha1G gene, a method of preparing the same and use thereof |
摘要 |
The disclosure concerns a method for resistance of epilepsy by suppressing the function of alpha 1G protein of T-type calcium channels, use of suppressor of alpha 1G protein for prevention or treatment for epilepsy, knockout mice resisting epilepsy by disrupting alpha 1G subunit of T-type calcium channel, and preparation method thereof. The alpha1G-knockout transgenic mouse can be used for investigating the relationship between diseases particularly neuropathy or psychopathy and the function of alpha1G T-type calcium channel via various behavioral tests since alpha1G subunit is mainly expression in central nervous system (CNS) and pheripheral nervous system (PNS). Further, the alpha1G-knockout transgenic mouse can be used for screening antileptic agents.
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申请公布号 |
US7626076(B2) |
申请公布日期 |
2009.12.01 |
申请号 |
US20070986671 |
申请日期 |
2007.11.23 |
申请人 |
ORIENT BIO., INC. |
发明人 |
SHIN HEE-SUP;KIM DAESOO;KEUM SEHOON;SONG INSEON |
分类号 |
A01K67/027;C12N15/00;G01N33/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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