| 摘要 |
The present invention relates to O-thiocarbamoyl-aminoalkanol compound represented by structural formula (VI) which are a racemic or enantiomerically enriched and pharmaceutically acceptable salts thereof t o treat diseases of the central nervous system: wherein Ar is a phenyl group as described in formula (1): wherein R is a member selected fro m the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br, and I, alkoxy containing 1 to 3 carbon atoms, thioalkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, or trifluorocarbon, and x is an integer from 1 to 3, with th e proviso that R is the same or different when x is 2 or 3. R1 and R2 and R3 and R4 respectively may be same or different from each other a nd are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, 3 to 7-membered aliphati c cyclic compounds and R3 and R4, together with the adjoining N-atom, form a 5 to 7-membered cyclic compound which optionally comprises ze ro to one additional nitrogen atoms substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups , or zero to one oxygen atoms directly unconnected, each of 1, m and n is zero or 1, and the pharmaceutically acceptable salts thereof.
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