| 摘要 |
Triptolide derivatives of Formula (I), their pharmaceutically acceptable salts and optical isomers, Formula (I): wherein, C5 and C6 are connect with each other by a C-C single bond or double bond; when C5 and C6 are connected with C-C single bond, X and Y represent independently hydrogen, oxygen, hydroxyl, halogen, lower alkyl-oxy, lower alkyl-amino, mercapto, lower alkyl-thio, the group of formula -OCOR, -OSO2OR or -OPO(OH)2, each of which is attached to C5 and C6, R represents -(CH2)nCO2Na, -(CO2)nCO2K, or -(CH2)nCH3, wherein n=1-6; Z represents hydrogen, oxygen, hydroxyl, halogen, lower alkyl-oxy, lower alkyl-amino, mercapto, lower alkyl-thio, the group of formula -OCOR, -OSO2OR or -OPO(OH)2, each of which is linked at C14-position, R represents -(CH2)nCO2Na, -(CO2)nCO2K, or -(CH2)nCH2, wherein n=1-6; wherein, the"______" linked with X, Y, and Z represents the stereochemistry orientations "<img id="CUSTOM-CHARACTER-00001" he="2.46mm" wi="6.35mm" file="US07626044-20091201-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/>" or "<img id="CUSTOM-CHARACTER-00002" he="2.46mm" wi="6.35mm" file="US07626044-20091201-P00002.TIF" alt="custom character" img-content="character" img-format="tif"/>" , but X and Y cannot both be hydrogen atom at the same time, methods for preparing the triptolides and their use as antiphiogistic agent, immunosuppressive agent or therapeutic agent for other related diseases.
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