| 摘要 |
THE PRESENT INVENTION RELATES TO COMPOUNDS OF GENERAL FORMULA1 WHEREIN R1 IS HALOGEN, -OR1, -SR1, CYCLOALKYL, CYCLIC AMIDE, HETEROCYCLOALKYL, ARYL OR 5-OR 6- MEMBERED HETEROAR-YL, CONTAINING ONE, TWO OR THREE HETEROATOMS, SELECTED FROM THE GROUP CONSISTING OF OXYGEN, SULPHUR OR NITROGEN; R1/R1"ARE HYDROGEN, LOWER ALKYL, LOWER ALKYL SUBSTITUTED BY HALOGEN, -(CH2)X CYCLOALKYL OR -(CH2)X-ARYL; IS -S(O)2-LOWER ALKYL, -S(O)2NH-LOWER ALKYL, NO2 OR CN; IS AN AROMATIC OR PARTIALLY AROMATIC BICYCLIC AMINE, WHICH MAY CONTAIN ONE OR TWO ADDITIONAL N-ATOMS, SELECTED FROM THE GROUP CONSISTING OF AND WHEREIN ONE OF THE ADDITIONAL N-RING ATOM MAY BE AVAILABLE IN FORM OF ITS OXIDE ARE HYDROGEN,HYDROXY,HALOGEN = O,LOWER ALKYL, CYCLOALKY,HETEROCYCLOALKYL,LOWER ALKOXY,CN,NO2,NH2,ARYL,5-OR-MEMBERED HETEROARYL CONTAINING ONE, TWO OR THREE HETEROATOMS, SELECTED FROM THE GROUP CONSISTING OF OXYGEN, SULPHUR OR NITROGEN, -NH-LOWER ALKYL, -N(LOWER ALKYL)2, CYCLIC AMIDE, -C(O)_CYCLIC AMIDE, S-LOWER ALKYL, -S(O)2 LOWER ALKYL, LOWER ALKYL SUBSTITUTED BY HALOGEN, LOWER ALKOXY SUBSTITUTED BY HALOGEN, LOWER ALKYL SUBSTITUTED BY HYDROXY, -O-(CH2)Y LOWER ALKOXY, -O(CH2)X - C(O)N(LOWER ALKYL)2, -C(O) LOWER ALKYL, O-(CH2)X-ARYL, -O-(CH2) CYCLOALKYL, O_(CH2)X -HETEROCYCLOALKYL, —C(O)O-LOWER ALKYL, -C(O)-NH-LOWER ALKYL, -C(O)-N(LOWER ALKYL)2, 2-OXY-5-AZA-BICYCLO[2.2. 1 ]HEPT-5-YL OR 3-OXA-8 AZA -BICYDO [3.2.1] OCT-8-YL; R’ AND R’’’ IN GROUP E) MAY FORM TOGETHER WITH —(CH2)4- A SIX MEMBERED RING; OR R, R’, R” AND R” ARE INDEPENDENTLY FROM EACH OTHER HYDROGEN OR LOWER ALKYL; AND WHEREIN ALL ARYL-, CYCLOALKYL, CYCLIC AMIDE, HETEROCYCLOALKYL OR 5 OR 6 MEMBERED HETEROARYL GROUPS AS DEFINED FOR R’, R”, R’” AND R3 TO R10 MAY BE UNSUBSTITUTED OR SUBSTITUTED BY ONE OR MORE SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF HYDROXY, =0, HALOGEN, LOWER AILCYL, PHENYL, LOWER ALKYL SUBSTITUTED BY HALOGEN OR LOWER ALKOXY; N,M,O,P,Q,R,S AND T ARE 1 OR 2; X IS 1 OR 2; AND TO PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.
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