| 摘要 |
A COMPOUND OF FORMULA (I)WHEREIN R REPRESENTS A RADICAL SELECTED FROM IN WHICH R7 IS HALOGEN, CYANO, C1-4 ALKYL, C1-4 ALKOXY, TRIFLUOROMETHYL OR TRIFLUOROMETHOXY; P IS AN INTEGER FROM 0 TO 3; R1 REPRESENTS HYDROGEN, HALOGEN, CYANO, C2-4 ALKENYL, 61-4 ALKYL OPTIONALLY SUBSTITUTED BY HALOGEN, CYANO OR C1-4 ALKOXY; R2 REPRESENTS HYDROGEN OR C1-4 ALKYL; R3 AND R4 INDEPENDENTLY REPRESENT HYDROGEN, C1-4 ALKYL OR R3 TOGETHER WITH R4 REPRESENT C3-7 CYCLOALKYL; RS REPRESENTS: PHENYL SUBSTITUTED BY 1 TO 3 GROUPS INDEPENDENTLY SELECTED FROM TRIFLUOROMETHYL, C1-4 ALKYL, CYANO, C1-4 ALKOXY, TRIFLUOROMETHOXY, HALOGEN OR (SO)RC1-4 ALKYL; NAPHTHYL SUBSTITUTED BY 1 TO 3 GROUPS INDEPENDENTLY SELECTED FROM TRIFLUOROMETHYL, C1-4 ALKYL, CYANO, C1-4 ALKOXY, TRIFLUOROMETHOXY, HALOGEN OR (SO)RC1-4 ALKYL; A 9 TO 10 MEMBERED FUSED BICYCLIC HETEROCYCLIC GROUP SUBSTITUTED BY 1 TO 3 GROUPS INDEPENDENTLY SELECTED FROM TRIFLUOROMETHYL, C1-4 ALKYL, CYANO, C1-4 ALKOXY, TRIFLUOROMETHOXY, HALOGEN OR (SO)RC1-4 ALKYL OR RS IS A S OR 6 MEMBERED HETEROARYL GROUP SUBSTITUTED BY 1 TO 3 GROUPS INDEPENDENTLY SELECTED FROM TRIFLUOROMETHYL , C1-4 ALKYL, CYANO, C1-4 ALKOXY, TRIFLUOROMETHOXY, HALOGEN OR (SO)RC1-4 ALKYL; R6 REPRESENTS HYDROGEN OR (CH2)QR8; RS REPRESENTS HYDROGEN, C3-7 CYCLOALKYL, C1-4 ALKOXRY, AMINE, C1-4 ALKYLAMINE, (C1-4ALKYL)2AMINE, OC(O)NRGR1 0 OR C(O)NRGR1 0; RG AND R10 INDEPENDENTLY REPRESENT HYDROGEN, C1-4 ALKYL OR C3-7 CYCLOALKYL; M REPRESENTS ZERO OR 1 ; N IS 1 OR2; Q IS AN INTEGER FROM 1 TO 4; R IS 1 OR 2; PROVIDED THAT WHEN RS IS PHENYL SUBSTITUTED BY 1 TO 3 GROUPS INDEPENDENTLY SELECTED FROM TRIFLUOROMETHYL, C1-4 ALKYL, CYANO, C1-4 ALKOXY, TRIFLUOROMETHOXY, HALOGEN OR (SO)RC1-4 ALKYL, R IS NOT THE RADICAL I) OR PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF; PROCESSES FOR THEIR PREPARATION TO PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY TACHYKININS AND/OR BY SELECTIVE INHIBITION OF SEROTONIN REUPTAKE TRANSPORTER PROTEIN.
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