| 摘要 |
1 19 MACROCYLIC INHIBITORS OF NEPATITIS C VIRUS ABSTRACT 5 INHIBITORS OF HCV REPLICATION OF FORI-NULA (1) R 4 R2, 0 N RLB R3@ NH-S(O)P-N / /RLA AND THE N-OXIDES, SALTS, AND STEREOISORNERS THEREOFWHEI EM EACH DASHED LINE REPRESENTS ,IN OPTIONAL DOUBLE BOND@ X IS N, CH AND WHERE X BEARS A DOUBLE BOND IT IS C; I 0 R" AND RIB ARE HYDROGEN, C3.7CYCIOALKVL ARYL, HET, CI-(,ALKOXV, CL-(,ALKYL OPTIONALLY SUBSTITUTED WITH HALO, CI-6ALKOXV, CYARIO, POLYHALOC,,,ALKOXY, C3-7CYCLOALKYL, ARYL, OR WITH HET; OR R" AND R LB TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED FORM A 4 TO 6 MEMBERED HETEROCYCLIC RING WHICH MAY BE OPTIONALLY SUBSTITUTED: L IS A DIRECT BOND, -0-, -0-CI-4ALKANEDIYL-, -0-CO-, -0-C(=O)-NR 5A OR 15 --0-C(=0)-NR"-CI4ALKANEDIYI-; R2 IS HYDROGEN, AND WHERE X IS C OR CH, R2 MAV ALSO BE CL-FIALKYL; R 3IS HYDROGEN, CL-TALKVI, CJ_6ALKOXYCL_(,ALKYI, CI-7CYCLOALKYL, AMINO, MONO- OR DIC,-6A]KYLAMINO; R 4IS ARYL OR A SATURATED, A PARTIALLY UNSATURATED OI- COMPLETELY UNSATURATED 5 OR 6 20 MEMBERED MONOCYCLIE OR 9 TO I 2 I-NEIRIBERC.1 VS'EM WHEREIN SAID RING SYSTEM CONTAINS ONE NITROGEN, AND OPTIONALLY ONE TO THREE ADDITIONAL HETEROATOMS SELECTED FROM 0, S AND N, AND WHEREIN THE REMAINING RING MEMBERS ARE CARBON ATOMS; WHEREIN SAID RING SYSTEM MAY BE OPTIONALLY SUBSTITUTED@ N IS 3, 4, 5, OR 6; P IS I OR 2-, 25 ARVI IS PHENYL, NAPHTHYL, INDANYL, OR 1.2,3,4-LETRAHYDRONAPHLHYL, EACH OF WHICH MAY BE OPTIONALLY SUBSTITUTED WITH ONE. TWO OR THREE SUBSTITUENM AND HET IS A 5 OR 6 MEMBERED SATURATED, PARTIALLY UNSATURATED OR COMPLETELY UNSALUR3LED HETEROCYCLIC RING CONTAINING I TO 4 HELLEROALORRIS SELECTED FROM N, 0 AND S, BEING OPTIONALLY CONDENSED WITH A BENZENE RING, AND WHEREIN HET INAY BE OPTIONAILY 30 SUBSTITUTED WITH ONE, TWO OR THREE SUBSTITUENTS:
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