| 摘要 |
The present invention relates to the discovery of a group of abnormal MHC class II presentation phenotypes, which are predictive of penetrance of a disorder characterized by abnormal MHC class II antigen presentation, e.g., in comparison to cells (even genetically identical cells) from individuals not afflicted with the disorder. The invention provides methods for detecting an individual's predisposition to develop a disorder associated with abnormal MHC class II presentation. The present invention is also directed to a method for treating a disease or disorder associated with abnormal MHC class II presentation (e.g., Type I diabetes) by effectively altering MHC class II presentation of an antigen presenting cell. |
