| 摘要 |
Disclosed is the use of a composition comprising a plurality of Neisseria meningitidis capsular saccharide conjugates in the manufacture of a medicament for preventing a disease caused by N meningitidis in a subject that has been pre-immunized with a tetanus toxoid and/or a conjugate of a capsular saccharide of an organism other than N. meningitidis and a tetanus toxoid, wherein said composition comprises at least two of (a), (b), (c) and (d) selected from the group consisting of: (a) a conjugate comprising (i) the capsular saccharide of serogroup A Neisseria meningitidis and (ii) a tetanus toxoid; (b) a conjugate comprising (i) the capsular saccharide of serogroup C N. meningitidis and (ii) a tetanus toxoid; (c) a conjugate comprising (i) the capsular saccharide of serogroup WI 35 N. meningitidis and (ii) a tetanus toxoid; and (d) a conjugate comprising (i) the capsular saccharide of serogroup Y N. meningitidis and (ii) a tetanus toxoid.
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