| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: present invention relates to ligand with a wide range of simultaneous receptor activity towards adrenergic 1A, 1B , 1D, 1A, 2A, 2, dopamine D1, D21, D2S, D3, serotonin 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5- HT7, sigma 1, 2 receptors, to calcium and sodium channels, monoamine transporters [norepinephrine (NET) and dopamine (DAT)], which is 3-methyl-9-benzyl-1,2,3,4-tetrahydrocarbonyl naphthalene-1,5-disulphonate of formula 1: ^ ^ . The invention also relates to a pharmaceutical composition, which has a medicinal origin, which is a ligand of formula 1 with the given range of simultaneous receptor activity for preventing and/or treating diseases of the central nervous system, pathogenesis of which is related to GPCR receptors, ion channels and monoamine transporters, method of preparing said composition, and to medicinal agents. ^ EFFECT: range of simultaneous activity towards said receptors increases capacity and effectiveness of using the said ligand. ^ 10 cl, 10 dwg, 7 ex
|
