| 摘要 |
Provided is a composition for forming a solid implant in situ within a body by exposure to body fluids, suitable for a controlled release of bioactive material, comprising (i) a biologically active agent, (ii) 10 to 25% by weight of the total composition of a pharmaceutically acceptable, biodegradable, thermoplastic polymer, which is a polylactide which is insoluble in aqueous media or human or animal body fluids, (iii) 50 to 80% by weight of the total composition of a pharmaceutically acceptable, biodegradable, water-insoluble or slightly water-soluble organic solvent, which is a triester of glycerin, and (iv) above 0 to up to 10% by weight of the total composition a pharmaceutically acceptable, water-soluble and biocompatible adjuvant selected from the group consisting of C2-C6alkanols, polyhydroxy alcohols and ketals. Further provided are implants made of said composition and a method of implanting the implant in a non-human animal body.
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