Mutations in ErbB2 associated with cancerous phenotypes

摘要

Provided is a naturally occurring cancer-associated mutant of a human ErbB2 polypeptide, comprising one or more somatic amino acid mutations, wherein the mutation is an amino acid insertion selected from the group consisting of ins774(AYVM) and ins779(VGS) or an amino acid substitution selected from the group consisting of L755P, E914K and G776S. Further provided are corresponding nucleic acids and antibodies and assays utilizing said mutations.