| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to chemically and physically stable compositions and sets, which contain factor VII polypeptide or a factor VII related polypeptide, which can be stored, handled and used at room temperature. A set is proposed, which contains a pharmaceutical drug which contains: a) a composition which contains factor VII polypeptide and a combination of sucrose and polyol, with moisture content of approximately not more than 3%, in form of a first separate composition, and a container for this first separate composition; and b) introduction carrier, which contains a solvent for reducing (dissolving) the said composition and histidine in amount approximately ranging from 0.1 mM to 100 mM, and possibly a toxicity modifying agent in an amount sufficient for making isotonic the reduced solution, obtained from dissolving the first separate composition in the introduction carrier of the second separate composition, in form of the second separate composition, and a container for this second separate composition. ^ EFFECT: invention provides for stability. ^ 21 cl, 9 ex, 6 tbl |
