发明名称 |
TARGETED DELIVERY TO HUMAN DISEASES AND DISORDERS |
摘要 |
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders. |
申请公布号 |
WO2009142525(A2) |
申请公布日期 |
2009.11.26 |
申请号 |
WO2009PT00027 |
申请日期 |
2009.05.21 |
申请人 |
UNIVERSIDADE DE COIMBRA;CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR;SERENO DE ALMEIDA MOREIRA, JOAO NUNO;DANTAS NUNES CALDEIRA DE MOURA, VERA LUCIA;DE MAGALHAES SIMOES, SERGIO PAULO;MONTEIRO PEDROSO DE LIMA, MARIA DA CONCEICAO |
发明人 |
SERENO DE ALMEIDA MOREIRA, JOAO NUNO;DANTAS NUNES CALDEIRA DE MOURA, VERA LUCIA;DE MAGALHAES SIMOES, SERGIO PAULO;MONTEIRO PEDROSO DE LIMA, MARIA DA CONCEICAO |
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