NOVEL GPR101 TRANSGENIC MICE AND METHODS OF USE THEREOF

摘要

Transgenic non-human animals, or cells isolated therefrom, whose genome comprises the GPRlOl gene knocked out and transgenic non-human animals, or cells isolated therefrom, whose genome comprises the GPRlOl gene constitutively active are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention or diagnosis of disease related to energy metabolism, including obesity, metabolic syndrome, dyslipidemia, insulin resistance syndrome, type 2 diabetes, anorexia nervosa and cachexia.