发明名称 |
Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation |
摘要 |
<p>The present invention provides methods for direct killing of cancer cells using anti-alpha5beta1 antibodies. Generally, the method comprises contacting a cancer cell that expresses alpha5beta1 on its surface with an anti-alpha5beta1 antibody, and thereby inducing the death of the cancer cell. The methods of the invention may be employed at an early stage of cancer development in a patient to prevent tumor establishment. In addition, the methods may be used to treat previously formed tumors especially in cancer that have not proven susceptible to anti-angiogenesis therapy. The methods may be employed as a combination therapy of anti-alpha5beta1 antibodies together with cancer chemotherapeutic agents or other molecular-based cancer therapeutic agents.</p> |
申请公布号 |
AU2005226736(B2) |
申请公布日期 |
2009.11.26 |
申请号 |
AU20050226736 |
申请日期 |
2005.03.24 |
申请人 |
FACET BIOTECH CORPORATION |
发明人 |
VINAY BHASKAR;SUN HO;RICHARD MURRAY;DEBBIE LAW;VANITHA RAMAKRISHNAN |
分类号 |
A61K39/00;A61K38/00;A61K39/395;A61K49/00;C07K16/00;C07K16/28 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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