发明名称 SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS
摘要 A compound of Formula (I): or a salt or solvate thereof, wherein: One of R1 and R2 is H and the other represents -NHCONHR4, wherein R4 represents a phenyl or naphthyl group which may be optionally substituted by one or more substituents independently selected from -C1-6 alkyl, -C1-6 haloalkyl, halogen, C1-6 alkoxy, C1-6 haloalkoxy, OH, NO2, C3-7 cycloalkyl, indanyl, or R4 together with the NH to which it is bonded forms a morpholino group; and R3 is H or NHR5 wherein R5 is H, -quinolinyl or -isoquinolinyl, -(CONH)p phenyl wherein p is 0 or 1 and the phenyl is optionally substituted by one or more substituents independently selected from halogen, -C1-6 alkyl, -C1-6 haloalkyl, -morpholino, -SO2NH2, and methyl substituted benzothiazole.
申请公布号 US2009291949(A1) 申请公布日期 2009.11.26
申请号 US20040595912 申请日期 2004.11.17
申请人 WASHIO YOSHIAKI 发明人 WASHIO YOSHIAKI
分类号 A61K31/4725;A61K31/47;A61K31/5377;C07D217/02;C07D217/14;C07D217/22;C07D401/12;C07D413/12;C07D417/12 主分类号 A61K31/4725
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