MANUFACTURING METHOD OF THERMO-ROD FOR ACTIVE DRUG RELEASE THE THERMO-ROD

摘要

Disclosed is a thermorod for active drug release capable of actively releasing drugs according to temperature and a method of manufacturing the same. The method for manufacturing a thermorod that generates heat by means of eddy current loss and hysteresis loss in an induced magnetic field comprises: processing the thermorod into a certain shape; preparing a mixed- drug specimen by mixing a drug with a high molecular compound acting as a support of the drug; and forming a mixed-drug layer on the surface of the thermorod by using the mixed-drug specimen. Therefore, the method and the thermorod prepared thereby may be useful to effectively perform the drug administration and anti-cancer drug treatment of affected parts since they may be used to perform local hyperthermia at 36.5°C or above and to actively control the active drug release and delivery according to temperature as well. Also, the method and the thermorod prepared thereby may be useful in the treatment of resting tumor cells along with hyperthermia by performing a surgical operation on lesion sites of biological tissues using the thermorod, and in minimizing the toxicity caused by an increase in blood drug concentration, which is generated when a drug is administered by a conventional method, since the drug is effectively delivered to an affected part in response to the active drug release.