USE OF PSEUDOMONAS AERUGINOSA ALKALINE PROTEASE (APRA) AND INHIBITORS THEREOF IN MEDICINE AND AGRICULTURE

摘要

The invention relates to an inhibitor of Pseudomonas aeruginosa alkaline protease for use in the treatment or prevention of infectious diseases in humans, animals and plants. The treatment suitably comprises inhibiting the interference of Pseudomonas aeruginosa alkaline protease with a microbial molecule that is recognized by receptors involved in innate immunity, in particular flagellin. The receptors involved in innate immunity are Toll-like receptors, in particular the Toll-like receptor 5 (TLR5), or the flagellin locus 2 (FLS2) receptor.