摘要 |
<p>Process for preparation of (S)-1 -phenyl-1, 2,3, 4-tetrahydroisoquinoline is characterized in that 1-phenyl-1,2,3, 4-tetrahydroisoquinoline is reacted with D-(-)- tartaric acid in a solvent system consisting of methanol and water, preferably at 3.3:1 to 1 :1 volume ratio, the crystallization mixture is left for crystallization and (S)-1-phenyl-1,2,3, 4-tetrahydroisoquinoline is released from obtained crystalline diastereoisomeric salt according to standard procedures. (S)-1-Phenyl- 1,2,3, 4-tetrahydroisoquinoline is the intermediate in enantiomeric synthesis of solifenacin.</p> |
申请人 |
ZAKLADY FARMACEUTYCZNE POLPHARMA SA;ZEGROCKA-STENDEL, OLIWIA;ZAGRODZKA, JOANNA;LASZCZ, MARTA |
发明人 |
ZEGROCKA-STENDEL, OLIWIA;ZAGRODZKA, JOANNA;LASZCZ, MARTA |