发明名称 |
HUMAN MONOCLONAL ANTIBODIES TO CTLA-4 |
摘要 |
<p>In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T- lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining- regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.</p> |
申请公布号 |
SG156547(A1) |
申请公布日期 |
2009.11.26 |
申请号 |
SG20080033698 |
申请日期 |
1999.12.23 |
申请人 |
PFIZER INC.;AMGEN FREMONT INC. |
发明人 |
HANSON DOUGLAS CHARLES;NEVEU MARK JOSEPH;MUELLER EILEEN ELLIOT;HANKE JEFFREY HERBERT;GILMAN STEVEN CHRISTOPHER;DAVIS C. GEOFFREY;CORVALAN JOSE RAMON |
分类号 |
A01H5/00;A01K67/027;A61K39/395;A61P29/00;A61P35/00;A61P37/02;A61P37/04;C07K16/00;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/02;C12N15/09;C12P21/08;C12Q1/02;G01N33/15;G01N33/50;G01N33/577;(IPC1-7):A61K39/395;C12N5/08 |
主分类号 |
A01H5/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|