发明名称 |
Method for producing 5-aryl nicotinaldehydes |
摘要 |
The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.
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申请公布号 |
USRE41008(E1) |
申请公布日期 |
2009.11.24 |
申请号 |
US20010371308 |
申请日期 |
2001.01.05 |
申请人 |
MERCK PATENT GMBH |
发明人 |
BATHE ANDREAS;BOKEL HEINZ;KNIERIEMEN RALF;MUERMANN CHRISTOPH;KEIL THOMAS |
分类号 |
C07D211/78;C07D213/78;C07D211/70;C07D213/30;C07D213/46;C07D213/48;C07D213/80;C07D213/803;C07D401/04;C07D405/12 |
主分类号 |
C07D211/78 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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