发明名称 |
Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology |
摘要 |
The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
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申请公布号 |
US7622272(B2) |
申请公布日期 |
2009.11.24 |
申请号 |
US20060517599 |
申请日期 |
2006.09.05 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
CUTTITTA FRANK;MARTINEZ ALFREDO |
分类号 |
G01N33/53;A01N37/18;A61K31/00;A61K38/00;A61K39/00;A61K39/395;A61P3/00;A61P3/10;A61P17/00;A61P19/00;A61P25/00;A61P31/00;A61P31/04;A61P31/10;A61P35/00;A61P37/00;A61P37/08;A61P43/00;C07K2/00;C07K4/00;C07K5/00;C07K14/00;C07K14/47;C07K14/575;C07K16/00;C07K16/18;C12N15/16;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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