发明名称 |
Methods for synthesizing mevalonate |
摘要 |
Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.
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申请公布号 |
US7622283(B2) |
申请公布日期 |
2009.11.24 |
申请号 |
US20060610690 |
申请日期 |
2006.12.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
KEASLING JAY D.;MARTIN VINENT J. J.;PITERA DOUGLAS J.;KIM SEON-WON;WITHERS, III SYDNOR T.;YOSHIKUNI YASUO;NEWMAN JACK;KHLEBNIKOV ARTEM VALENTINOVICH |
分类号 |
C12P1/00;C07H21/04;C12N1/20;C12N1/21;C12N9/00;C12N9/02;C12N9/10;C12N9/12;C12N9/88;C12N15/00;C12N15/74;C12P7/00;C12P7/42;C12P9/00 |
主分类号 |
C12P1/00 |
代理机构 |
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地址 |
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