| 摘要 |
A process for the separation of a fragment antibody from a medium is provided. The process comprises contacting the medium comprising the fragment antibody with a synthetic affinity ligand attached to a support matrix under conditions whereby the fragment antibody binds to the synthetic affinity ligand. The synthetic affinity ligand has the formula (I): wherein Q represents an attachment to a solid support matrix, optionally via a spacer group; A and B are each independently -Y-phenyl or -Y-naphthyl groups substituted with one or more substituents capable of hydrogen bonding, preferably one or more of -OH, -SH or - CO2H groups; each Y independently represents -NR-, -O- or -S-; and each R independently represents H or a C1-4 alkyl group.
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