PROCESS FOR PRODUCTION OF CIS-4-HYDROXY-L-PROLINE

摘要

The object is to develop a process for producing cis-4-hydroxy-L-proline economically and efficiently. Thus, disclosed is L-proline cis-4-hydroxylase.  This enzyme may be derived from a bacterium Mesorhizobium loti which is a leguminous bacterium specific to birdsfoot trefoil or a bacterium Sinorhizobium meliloti which is a leguminous bacterium specific to alfalfa.  Also disclosed is a process for producing cis-4-hydroxy-L-proline from L-proline by using the enzyme.  Further disclosed is a recombinant vector carrying a polynucleotide encoding the enzyme.  Still further disclosed is a transformant harboring the vector.