发明名称 |
Epidermal Growth Factor Receptor Antagonists and Methods of Use |
摘要 |
The present invention features epidermal growth factor receptor (EGFR) antagonists. These EGFR antagonists are polypeptide variants of ligands of EGFR. The EGFR ligand polypeptide variants of the invention possess EGFR antagonistic properties and can inhibit at least one EGFR-mediated biological activity such as inhibition of the receptor's kinase activation activity and subsequently, cell proliferation. Such polypeptide variants, and nucleic acids encoding these polypeptide variants can be used therapeutically in situations in which inhibition of EGFR activity is indicated. |
申请公布号 |
US2009286729(A1) |
申请公布日期 |
2009.11.19 |
申请号 |
US20080261233 |
申请日期 |
2008.10.30 |
申请人 |
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发明人 |
BISHOP JEFFREY S.;LOOMIS A. KATRINA;MONTICELLO DANIEL J.;PIENKOS PHILIP T. |
分类号 |
A61K38/16;A61P17/06;A61P35/00;C07K14/485 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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