ACTIVATED NITRIC OXIDE DONORS AND METHODS OF MAKING AND USING THEREOF
摘要
Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O 2 -aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O 2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment and prevention are also described herein.
申请公布号
WO2009114368(A3)
申请公布日期
2009.11.19
申请号
WO2009US36100
申请日期
2009.03.05
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;SHAMI, PAUL, J.;KOSAK, KEN, M.