发明名称 |
INHIBITION OF ALPHA-SYNUCLEIN AGGREGATION |
摘要 |
This invention relates to the inhibition of alpha-synuclein aggregation using peptidyl compounds which are retroenantiomers of the alpha-synuclein sequence, in particular retroenantiomers of sequences in the regions between residues 1 to 60 or residues 61 to 96. Peptidyl compounds of the invention may optionally be coupled to doperminergic targeting moieties and/or blood brain barrier transport moieties and may be useful in the treatment of alpha-synucleinopathies such as Parkinson's disease.
|
申请公布号 |
US2009286745(A1) |
申请公布日期 |
2009.11.19 |
申请号 |
US20070307081 |
申请日期 |
2007.07.02 |
申请人 |
ZAPALOID LIMITED |
发明人 |
ZURDO JESUS;FOWLER SUSAN;STALLWOOD YVETTE;GIRALT ERNEST;TEIXIDO MERITXELL;CARULLA NATALIA |
分类号 |
A61K38/08;A61K38/07;C07K5/10;C07K7/06 |
主分类号 |
A61K38/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|