发明名称 |
CONJUGATES FOR THE TREATMENT OF MESOTHELIOMA |
摘要 |
The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers. |
申请公布号 |
WO2009138396(A2) |
申请公布日期 |
2009.11.19 |
申请号 |
WO2009EP55704 |
申请日期 |
2009.05.12 |
申请人 |
MOLMED S.P.A.;BORDIGNON, CLAUDIO;LAMBIASE, ANTONIO |
发明人 |
BORDIGNON, CLAUDIO;LAMBIASE, ANTONIO |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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地址 |
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