| 摘要 |
#CMT# #/CMT# Cosmetic composition with improved anti-free radical activity, comprises a combination of at least three of anti-free radical substances such as: a combination of ebselen and idebenone; and at least two anti-free radicals substances such 2-methyl-chroman-6-ol derivative (I), its esters with 2-4C organic acids e.g. acetate, propionate, isopropionate, butyrate or isobutyrate, edelweiss extract, emblica extract and N-acetyl cysteine. #CMT# : #/CMT# Cosmetic composition with improved anti-free radical activity, comprises a combination of at least three of anti-free radical substances such as: a combination of ebselen and idebenone; and at least two anti-free radicals substances such 2-methyl-chroman-6-ol derivative of formula (I), its esters with 2-4C organic acids e.g. acetate, propionate, isopropionate, butyrate or isobutyrate, edelweiss extract, emblica extract and N-acetyl cysteine. R : 1-16C hydrocarbon chain, preferably methyl, -(CH2-CH2-CH2-CH(CH3))3-CH3 or -(CH2-CH2-CH=C(CH3))3-CH3; and R1-R3H, CH3 or OCH3. An independent claim is included for cosmetic care, comprises determination of at least one zone of the skin, superficial body growth or hair of a person for care and/or protection against free radicals and topical application of the composition on the zone to prevent and/or fight against the damages caused by free radicals. #CMT#[Image]#/CMT# #CMT#ACTIVITY : #/CMT# Dermatological. #CMT#MECHANISM OF ACTION : #/CMT# None given. #CMT#USE : #/CMT# The composition is useful as an agent for the manufacture of a cosmetic composition with anti-free radical activity. The composition is useful in cosmetic care for care and/or protection against free radicals, to prevent and/or fight against the damages caused by free radicals, particularly for anti-wrinkle care (all claimed). The anti-oxidant property of the composition was tested. The results showed that the combination of ebselen, alpha-tocotrienol and idebenone exhibited 67.13% reduction of the free radicals. #CMT#ADVANTAGE : #/CMT# The composition exhibits improved anti-oxidant property (claimed). #CMT#PHARMACEUTICALS : #/CMT# Preferred Composition: The composition further comprises vitamin C or its derivatives. The composition comprises ebselen, idebenone and alpha-tocotrienol or edelweiss extract. The composition comprises ebselen (0.02-0.2 wt.%), idebenone (0.02-0.2 wt.%), 2-methyl-chroman-6-ol derivative (I) (0.01-1 wt.%), edelweiss extract (0.01-1 wt.%), emblica extract (0.02-2 wt.%) and N-acetyl cysteine (0.02-2 wt.%). Preferred Components: (I) is alpha-tocopherol, alpha-tocotrienol and/or dimethylmethoxychromanol. #CMT#ADMINISTRATION : #/CMT# Administration of the composition is topical (claimed). #CMT#EXAMPLE : #/CMT# Anti-wrinkle cream comprised (in %): glyceryl stearate and polyethylene glycol stearate (6); hydrogenated polyisobutene (3); squalane (3); caprylal triglyceride/glycerol caprate (3); glycerin (2); octyl methoxy cinnamate (2); cetostearyl octanoate (1.5); bee wax (1.5); cetyl alcohol (1); stearylic alcohol (1); dimethicone (1); xanthan gum (0.2); idebenone (0.02); alpha-tocotrienol (0.1); N-acetyl cysteine (0.2); preservatives, perfumes and dyes (required quantity); and water (to make up to 100%). |
