发明名称 |
IMMUNOINTERACTIVE MOLECULES |
摘要 |
The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothielial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B. Accordingly, a method of screening for inhibitors of the biological activity of VEGF-B is also provided.
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申请公布号 |
US2009285831(A1) |
申请公布日期 |
2009.11.19 |
申请号 |
US20090403897 |
申请日期 |
2009.03.13 |
申请人 |
ZENYTH OPERATIONS PTY LTD |
发明人 |
NASH ANDREW;MACCARONE GIUSEPPE;SCOTNEY PIERRE DAVID |
分类号 |
A61K39/395;A61P35/00;A61P37/00;C07K14/52;C07K14/71;C07K16/22;C12N5/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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