| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for constructing a sugar chain useful for preparation etc., of artificial proteoglycans or artificial glycosaminoglycans. <P>SOLUTION: The method for constructing the sugar chain is characterized by carrying out oxymercuration of an unsaturated bond in an unsaturated hexuronic acid of an oligosaccharide having the unsaturated hexuronic acid at the nonreducing terminal (with the proviso that a mercury salt to be used is 5 molar equivalents at the maximum based on the oligosaccharide), and the subsequent reductive demercuration, thereby converting the unsaturated hexuronic acid at the nonreducing terminal into hexuronic acid, and then conducting glycosylation of the hexuronic acid. Thereby, a new methodology for extending the sugar chain by converting the unsaturated hexuronic acid at the nonreducing terminal into the hexuronic acid, and conducting the glycosylation of the hexuronic acid is provided. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
