The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
申请公布号
WO2008112286(A3)
申请公布日期
2009.11.19
申请号
WO2008US03351
申请日期
2008.03.12
申请人
NEKTAR THERAPEUTICS;RIGGS-SAUTHIER, JENNIFER;DENG, BO-LIANG;REN, ZHONGXU;ZHANG, WEN;GU, XUYUAN;DUARTE, FRANCO, J.
发明人
RIGGS-SAUTHIER, JENNIFER;DENG, BO-LIANG;REN, ZHONGXU;ZHANG, WEN;GU, XUYUAN;DUARTE, FRANCO, J.