PREPARATION OF MICRO OR NANO SYSTEMS DETECTABLE IN BIOLOGICAL ENVIRONMENTS BASED ON INORGANIC OXIDES WITH CONTROLLED POROSITY FOR CARRYING BIOLOGICALLY ACTIVE OR ACTIVABLE SUBSTANCES

摘要

The invention described therein is a modular methodic for the preparation of inorganic oxides-based micro- and nanodevices with regular porosity of potential use as carriers of active or activables biological species. The inorganic-micellar composites obtained through the synthesis procedures are functionalized, using suitable reactants according to post-synthetic grafting procedures or starting directly from the synthesis mixture. Successively, on the first function are anchored biological functions with different chemical properties aimed to allow the detection of the systems in biological fluids (marker) and to the active targeting of the system through molecular or biological recognition (targeting). The marker and targeting species can be part of the systems jointly or separately without affecting the peculiarity of the invention concerning with systems for the intra- or extracellular targeting of biologically active substances. The grafting of the marker and targeting functions takes place selectively on the external surface because is carried out starting from the initial inorganic-micellar composite material. The next step consists in the removal of the template carried out using treatments which leave unchanged the biological activity of the marker and targeting functions. The obtained pore volume is used for the immobilization and further release of active substances or therapeutic agents with different nature and size.