发明名称 PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN
摘要 <p>The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.</p>
申请公布号 EP1532098(B1) 申请公布日期 2009.11.18
申请号 EP20030747879 申请日期 2003.08.06
申请人 NICOX S.A. 发明人 DEL SOLDATO, PIERO;SANTUS, GIANCARLO;BENEDINI, FRANCESCA
分类号 A61K31/618;C07C201/02;A61K31/216;C07B61/00;C07C67/10;C07C69/734;C07C201/04;C07C201/08;C07C203/00;C07C203/04;C07C269/06;C07C271/28 主分类号 A61K31/618
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