| 发明名称 |
REGIONES DE CADENA PESADA VARIABLE Y LIVIANA VARIABLE; ACIDOS NUCLEICOS QUE LAS CODIFICAN; METODO DE PRODUCCION; ANTICUERPOS ANTI-NOTCH3 QUE LAS COMPRENDEN; Y USO DE LOS ANTICUERPOS PARA TRATAR ENFERMEDADES RELACIONADAS CON EL RECEPTOR NOTCH3. |
| 摘要 |
<p>The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibits its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.</p> |
| 申请公布号 |
CL2007003661(A1) |
申请公布日期 |
2008.07.18 |
| 申请号 |
CL20070003661 |
申请日期 |
2007.12.17 |
| 申请人 |
GENENTECH, INC. |
发明人 |
LI, KANG, ZHOU, BIN-BING STEPHEN, LI, YUCHENG, FUNG, SEK CHUNG, SINGH, SANJAYA. |
| 分类号 |
A61K39/395;A61P35/00;C07K16/28;C12N15/13 |
主分类号 |
A61K39/395 |
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