发明名称 |
TARGETING MACROPHAGES THROUGH SIALOADHESIN |
摘要 |
Methods of delivering a cargo moiety to a cell is provided according to embodiments of the present invention which includes contacting a cell expressing sialoadhesin with a conjugate including a sialoadhesin binding moiety and a cargo moiety. The sialoadhesin binding moiety binds to the sialoadhesin expressed by the cell and is internalized along with the cargo, delivering the cargo moiety to the cell. Particular methods provided by the present invention include induction or enhancement of sialoadhesin expression in a cell which naturally produces little or no sialoadhesin. Induction or enhancement of sialoadhesin expression includes transfection of a sialoadhesin expression construct and/or administration of an agent effective to induce or enhance sialoadhesin expression. Methods and compositions for stimulating an immune response in a subject are detailed. Particular methods and compositions for stimulating an immune response to a virus are provided by the present invention. |
申请公布号 |
WO2008093166(A3) |
申请公布日期 |
2009.11.19 |
申请号 |
WO2007IB04499 |
申请日期 |
2007.05.11 |
申请人 |
GHENT UNIVERSITY;NAUWYNCK, HANS;DELPUTTE, PETER |
发明人 |
NAUWYNCK, HANS;DELPUTTE, PETER |
分类号 |
A61K47/48;A61P35/00;A61P37/04 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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