发明名称 |
Methods of diagnosing muscle damage |
摘要 |
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilament protein modification product. Preferably, the myofilament protein modification product is a chemical adduct of a myofilament protein. The method can also be used to assess the extent and/or type of muscle damage in a subject by studying the profile of myofilament protein modification products detected in the sample taken from the subject. The invention further provides a method for screening for an agent which modulates the level of a myofilament protein modification product an present in a biological sample or for a calcium sensitizing agent. The invention is applicable to cardiac muscle and skeletal muscle.
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申请公布号 |
US7618782(B1) |
申请公布日期 |
2009.11.17 |
申请号 |
US19990419901 |
申请日期 |
1999.10.18 |
申请人 |
QUEEN'S UNIVERSITY AT KINGSTON |
发明人 |
VAN EYK JENNIFER E.;LABUGGER RALF;NEVEROVA IRENA |
分类号 |
G01N33/53;G01N33/543;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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