发明名称 |
REGIOSELECTIVE AND STEREOSELECTIVE OXIDATION OF FUSED RING SYSTEMS USEFUL FOR THE PREPARATION OF AMINOSTEROLS |
摘要 |
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is de-scribed. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
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申请公布号 |
CA2406847(C) |
申请公布日期 |
2009.11.17 |
申请号 |
CA20012406847 |
申请日期 |
2001.04.12 |
申请人 |
GENAERA CORPORATION |
发明人 |
MICHALAK, RONALD;KINNEY, WILLIAM A.;ZHANG, XUEHAI |
分类号 |
C07J21/00;C07B61/00;C07J9/00;C07J31/00;C07J41/00 |
主分类号 |
C07J21/00 |
代理机构 |
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