发明名称 |
CHEMICALLY MODIFIED OLIGONUCLEOTIDE FOR SITE-DIRECTED MUTAGENESIS |
摘要 |
A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the mutagen is brought into proximity with the target molecule and causes a mutation at a specific site therein. The mutation activates, inactivates or alters the activity and function of t he target molecule.
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申请公布号 |
CA2166079(C) |
申请公布日期 |
2009.11.17 |
申请号 |
CA19942166079 |
申请日期 |
1994.06.24 |
申请人 |
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发明人 |
GLAZER, PETER;HAVRE, PAMELA A. |
分类号 |
C12N15/09;A61K31/70;A61K48/00;A61P31/12;A61P35/00;C07H21/00;C07H21/04;C12N15/00;C12N15/01;C12N15/10;C12N15/113;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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