发明名称 |
1-Ä(ADAMANTYL)ALKYLÜ-3- Ä(PYRIDINYL)ALKYLÜHARNSTOFF-VERBINDUNGEN ALS TNF- .ALPHA HEMMER ZUR BEHANDLUNG VON AUTOIMMUNERKRANKUNGEN |
摘要 |
A purpose of the present invention is to provide TNF- alpha production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula Ä1Ü or salts thereof according to the present invention have excellent TNF- alpha production inhibitory activities, <CHEM> wherein "A" is -(NR<4>)-, -(CR<5>R<6>)- or -O-, "B" is alkylene or alkenylene, R<1>, R<2>, R<4>, R<5> and R<6> are hydrogen, alkyl, alkenyl or the like, R<3> is aryl or unsaturated heterocycle, R<7> is hydrogen or alkyl, "X" is O or S, and "n" is an integer of 1 to 5. |
申请公布号 |
AT448204(T) |
申请公布日期 |
2009.11.15 |
申请号 |
AT20060076696T |
申请日期 |
2001.05.31 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD. |
发明人 |
BAN MASAKAZU;SUHARA HIROSHI;HORIUCHI, MASATO;YAMAMOTO, NORIYOSHI;ENOMOTO, HIROSHI;INOUE, HIROYUKI |
分类号 |
C07D213/40;C07D233/61;A61K31/16;A61K31/18;A61K31/417;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/4425;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/4525;A61K31/4545;A61K31/4709;A61K31/4725;A61K31/496;A61K31/513;A61K31/5377;A61P29/00;A61P37/00;A61P37/06;A61P43/00;C07C275/24;C07C311/39;C07D213/30;C07D213/32;C07D213/36;C07D213/38;C07D213/55;C07D213/56;C07D213/59;C07D213/68;C07D213/74;C07D213/75;C07D215/12;C07D401/06;C07D401/12;C07D405/12;C07D409/12;C07D417/12;C07D487/04 |
主分类号 |
C07D213/40 |
代理机构 |
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