发明名称 |
Dimeric Small Molecule Potentiators of Apoptosis |
摘要 |
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
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申请公布号 |
US2009281155(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
US20090509218 |
申请日期 |
2009.07.24 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
HARRAN PATRICK G.;WANG XIAODONG;DE BRABANDER JEF K.;LI LIN;THOMAS RANNY MATHEW;SUZUKI HIDETAKA |
分类号 |
A61K31/421;A61K31/165;A61K31/41;A61P35/00;A61P37/06;C07D257/04;C07D263/08;C12Q1/02 |
主分类号 |
A61K31/421 |
代理机构 |
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代理人 |
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地址 |
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