发明名称 |
METHODS AND COMPOSITIONS FOR THE DISPLAY OF POLYPEPTIDES ON THE PILI OF GRAM-POSITIVE BACTERIA |
摘要 |
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of interest is amino terminal to a Gram-positive bacterial pilus tip protein or an active variant or fragment thereof, wherein the active variant or fragment comprises a cleaved cell wall sorting signal (CWSS) motif. The Gram-positive bacterium displaying a polypeptide of interest on the tip of pili that are disclosed herein are useful, for example, in methods for immunizing a subject with an antigen and methods for removing contaminants from a composition. |
申请公布号 |
WO2009137763(A2) |
申请公布日期 |
2009.11.12 |
申请号 |
WO2009US43286 |
申请日期 |
2009.05.08 |
申请人 |
EMORY UNIVERSITY;SCOTT, JUNE;ZAEHNER, DOROTHEA;QUIGLEY, BERNARD |
发明人 |
SCOTT, JUNE;ZAEHNER, DOROTHEA;QUIGLEY, BERNARD |
分类号 |
C07K14/315;C12N1/21;C12N15/31;C12R1/46;G01N33/569 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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