AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS
摘要
Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC50 values both in a cell-free binding assay and in the inhibition of CD154-induced B-cell proliferation assay. The compounds may be used as therapeutic compounds for treatment of diseases and disorders related to immune or inflammatory responses. Methods of inhibiting the CD40/CD154 protein-protein interaction and treating diseases and disorders related to immune or inflammatory responses are described.
申请公布号
WO2009137471(A2)
申请公布日期
2009.11.12
申请号
WO2009US42831
申请日期
2009.05.05
申请人
UNIVERSITY OF MIAMI;BUCHWALD, PETER;MARGOLLES-CLARK, EMILIO;KENYON, NORMA, S.;RICORDI, CAMILLO