摘要 |
The present invention relates to a component for a malaria vaccine comprising: a) an immunogenic particle RTS, S and/or b) an immunogenic particle derived from the CS protein of one or more P. vivax strains and S antigen from Hepatitis B and optionally unfused S antigen, or c) an immunogenic particle comprising RTS, CSV-S and optionally unfused S antigen, and d) a stabilizing agent comprising a stabilizing agent with at least one thiol functional group, or mixtures thereof. Methods for preparing the component, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the component and use of the latter, particularly in therapy are also disclosed. |
申请人 |
GLAXOSMITHKLINE BIOLOGICALS S.A.;LEMOINE, DOMINIQUE, INGRID;WAUTERS, FLORENCE, EMILIE, JEANNE, FRANCOISE |
发明人 |
LEMOINE, DOMINIQUE, INGRID;WAUTERS, FLORENCE, EMILIE, JEANNE, FRANCOISE |