发明名称 |
Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors |
摘要 |
The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6; and then (b) a biochemical screening step to further select compounds which inhibit activation of a member of the IL-6 signaling pathways by a biochemical means from the compounds selected in step (a). The present invention also provides compounds which inhibit activation of a member of the IL-6 signaling pathways identified using said methods.
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申请公布号 |
US2009280483(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
US20080085324 |
申请日期 |
2008.05.21 |
申请人 |
KITAMURA TOSHIO;KAWASHIMA TOSHIYUKI |
发明人 |
KITAMURA TOSHIO;KAWASHIMA TOSHIYUKI |
分类号 |
C12Q1/02;C07C49/213;C07C49/255;C07C215/20;C07C275/28;C07D277/38;C07D333/68;C12Q1/48;C12Q1/68 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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