发明名称 |
Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof |
摘要 |
The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or prevention of neuromuscular disorders, preferably myasthenia gravis. In addition, it can penetrate the blood-brain barrier (BBB) and destroy AChE-R within central nervous system neurons, while also serving as a carrier to transport molecules across the BBB.
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申请公布号 |
US2009281165(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
US20080287274 |
申请日期 |
2008.10.07 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY |
发明人 |
SOREQ HERMONA;SAIDMAN SHLOMO;SAIDMAN JACKILINE;EVRON TAMA |
分类号 |
A61K31/7088;C12N15/09;A61K38/00;A61K48/00;A61P21/00;A61P21/02;A61P21/04;A61P25/00;C07H21/04;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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