| 摘要 |
<P>PROBLEM TO BE SOLVED: To identify a hypoxia-regulated gene. <P>SOLUTION: Provided are a purified, isolated and cloned specific nucleic acid sequence encoding a hypoxia-regulated gene, its protein and an antibody directed against the protein. Further provided are a transgenic animal and cell line as well as a knock-out organism of these sequences, a method of regulating angiogenesis or apoptosis, and a method for regulating response to hypoxic conditions in a patient in need of such treatment. Also provided is a method of diagnosing the presence of ischemia in a patient including the steps of analyzing a bodily fluid or tissue sample from the patient for the presence of a gene product of at least one expressed gene (up-regulated) as set forth in the group comprising specific sequences and judging as ischemia when the up-regulated gene or gene product is ascertained. <P>COPYRIGHT: (C)2010,JPO&INPIT |
