发明名称 |
Mesothelin, A Differentiation Antigen Present On Mesothelium, Mesotheliomas, and Ovarian Cancers and Methods and Kits for Targeting the Antigen |
摘要 |
This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and/or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection.
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申请公布号 |
US2009280556(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
US20080021151 |
申请日期 |
2008.01.28 |
申请人 |
THE GOVT. OF THE U.S.A. AD REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES |
发明人 |
PASTAN IRA;CHANG KAI |
分类号 |
C12N1/21;C07H21/04 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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