Disclosed are compounds of the formula I which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
申请公布号
CA2722811(A1)
申请公布日期
2009.11.12
申请号
CA20092722811
申请日期
2009.05.01
申请人
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人
COOK, BRIAN NICHOLAS;HARCKEN, CHRISTIAN;LEE, THOMAS WAI-HO;LIU, PINGRONG;MAO, CAN;LORD, JOHN;MAO, WANG;RAUDENBUSH, BRIAN CHRISTOPHER;RAZAVI, HOSSEIN;SARKO, CHRISTOPHER RONALD;SWINAMER, ALAN DAVID